KMID : 1149220160240020071
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Korean Journal of Oriental Medical Prescription 2016 Volume.24 No. 2 p.71 ~ p.79
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A Comparative Study on the Herbal Prescription and the Herbal Substance of Atractylodis Rhizoma Alba by HPLC analysis
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Cho Hyun-Joo
Jeon Yoon-Jae Kim Nam-Gil Choi Hyug-Yong
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Abstract
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Objectives : To verify the equivalence between Atractylodis Rhizoma Alba herbal prescription(HP-ARA) and Atractylodis
Rhizoma Alba herbal sub stance(HS-ARA).
Methods : Safety tests by microbial regulation and heavy metal analysis (total heavy metal, Pb, As) and a stability test by long term shelf test for HP-ARA according to notification of the Ministry of Food and Drug Safety were carried out. Then, multi component profile of HP-ARA and HS -ARA were analyzed by HPLC.
Results : The safety and stability of HP-ARA confirmed by several tests. Correlation coefficient of equivalence of HP-ARA and ARA-HS showed 0.992.
Conclusion: : Based on this result of equivalence between HP-ARA and HS-ARA, HP-ARA can substitute HS-ARA used to make herbal medicines (herbal decoction, pills and powder).
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KEYWORD
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Herbal medicines, Atractylodis Rhizoma Alba, Safety, Stability, Correlation coefficient
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